Endocrine Abstracts

The aim of study was to recurrently follow quality of life in type 1 diabetes patients after multiple educations and counseling. Ninty six patients of the age group of “between” 10 to 25 were initially examined in 2004 and Eighty eight patients of them were reexamined in 2006 after multiple counseling with diabetologist and trained diabetes educator at dia care, Ahmedabad, Gujarat, India. Quality of life was defined as perceived well being and life satisfaction, glob...

The study was aimed to compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin infusion pump (CSII) or multiple insulin injections (MDI). Total 14 patients were treated with insulin pump and 20 patients were treated with multiple injections; were mainly investigated for HbA1c, incidence of hypoglycemia, fetal outcome, rates of pregnancy induced hypertension and cesarean section. HbA1c with insulin pump was significantly bet...

Introduction: In the United Kingdom, the prevalence of type 1 diabetes in the under-15s is rising fast, an increase of 80% is expected by 2020 and even higher, 125%, in the under five age group. The National Service Framework Standard recommends that all children/young adults with diabetes should receive consistently high quality care and they, with their families, be supported to optimise the control of their blood glucose and all aspects of their subsequent development.<...

Background: The geographical difference in presentation of primary hyperparathyroidism (PHPT) is well known however, there is spare literature on influence of age and gender on presentation of PHPT.Objective: To study the effect of age and gender on clinical and biochemical presentation of PHPT.Method: This is a retrospective analysis of 184 histopathologically proven PHPT patients between March 1990 and March 2010 from a single ce...

Aims: Low vitamin D levels may contribute to the pathogenesis of bone disease in thalassaemia major patients. Our haematology department serves one of the UK’s largest populations of thalassaemia patients. We evaluated our thalassaemia major patients’ vitamin D levels and other serum bone markers.Methods: Blood specimens were collected from all thalassaemia major patients under active follow-up in March and April 2010 and serum 25-OH-vitamin D,...

AMPK is a key regulator of cellular and body energy homeostasis. We previously demonstrated that AMPK activation in osteoblasts increases bone formation in vitro while deletion of the AMPKα1 subunit leads to decreased bone mass in vivo. To determine whether bone turnover can be stimulated in the absence of AMPKα1 subunit, we subjected WT and AMPKα1−/− mice to catabolic (ovariectomy: OVX) and anabolic (intermittent PTH adminis...

Aims: Endocrine deficiencies are common complications of thalassaemia major. Our haematology department serves one of the UK’s largest populations of thalassaemia patients. We assessed our thalassaemia major patients’ endocrine status and factors associated with endocrinopathies.Methods: Retrospective analysis of our thalassaemia major patients on active follow-up in April 2010. Parameters such as age, gender, hepatitis C infection, compliance ...

Introduction: In paediatric practice hydrocortisone (HC) is frequently prescribed in doses of ≤2.5 mg. HC tablets are only available in 10 mg strengths or as 2.5 mg Corlan pellets, a formulation designed for oro-mucosal delivery. Thus, tablets are segmented to obtain an appropriate dose. This study examines the accuracy of obtaining 2.5 mg HC doses from quartered tablets.Materials and methods: Of 10 mg Hydrocortone tablets were studied. Weight unif...

We present the case of a 57 year old male that presented to a tertiary centre with a week’s history of lethargy, muscle cramps and peri-oral paraesthesia. He was otherwise fit and well. His examination revealed no evidence of Chvostek’s, Trousseau’s or tetany. His reflexes were not assessed. Initial electrolyte screening confirmed a hypocalcaemia with a serum adjusted calcium of 1.47 mmol/l (2.2–2.6), his phosphate was elevated at 1.64 mmol/l (0.8–1.5)...

Background: Polycystic ovary syndrome (PCOS) occurs in women of reproductive age and is characterized by hyperandrogenism, polycystic ovaries, oligomenorrhea or amenorrhea. Estimated prevalence is at least 6.5%. Women having PCOS tend to be overweight or obese. In addition to endocrine, metabolic and gynecological, features of PCOS, a number of psychological problems add up which affect quality of life and psychological well-being in women with PCOS.Mate...